A TRIFfic perspective on acute lung injury
- PMID: 18423191
- PMCID: PMC7112263
- DOI: 10.1016/j.cell.2008.04.006
A TRIFfic perspective on acute lung injury
Abstract
Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.
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Comment on
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Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.Cell. 2008 Apr 18;133(2):235-49. doi: 10.1016/j.cell.2008.02.043. Cell. 2008. PMID: 18423196 Free PMC article.
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