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Review
. 2008 Jun;12(3):292-6.
doi: 10.1016/j.cbpa.2008.03.009. Epub 2008 May 14.

Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner  1 , Hongchang Qu, Victor J Hruby
Affiliations
Review

Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner et al. Curr Opin Chem Biol. 2008 Jun.

Abstract

The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

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Figures

Figure 1
Figure 1
External β-turn dipeptide mimetics
Figure 2
Figure 2
Azabicycloalkanone amino acid scaffolds.
Figure 3
Figure 3
Peptide bond isosteres.
See this image and copyright information in PMC

References

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