Review
doi: 10.1111/j.1365-2826.2008.01682.x.
Cannabinoid type 1 receptor: another arrow in the adipocytes' bow
Affiliations
- PMID: 18426512
- DOI: 10.1111/j.1365-2826.2008.01682.x
Item in Clipboard
Review
Cannabinoid type 1 receptor: another arrow in the adipocytes' bow
J Neuroendocrinol.
2008 May.
Abstract
The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue, including cell proliferation, differentiation and secretion. Here, we will review the effects of cannabinoid type 1 (CB(1)) receptor activation/blockade in adipocytes by summarising the data in the literature since the discovery of the presence of this receptor in adipose tissue. We will also discuss our original data obtained in mouse 3T3-L1 adipocyte cells using WIN55 212, a CB(1)/CB(2) receptor agonist and SR141716 (rimonabant), a specific CB(1) receptor antagonist, respectively, in different experimental settings.
Similar articles
-
The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells.Mol Pharmacol. 2003 Apr;63(4):908-14. doi: 10.1124/mol.63.4.908. Mol Pharmacol. 2003. PMID: 12644592
-
Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon.Pharmacol Res. 2007 Aug;56(2):132-9. doi: 10.1016/j.phrs.2007.04.019. Epub 2007 May 10. Pharmacol Res. 2007. PMID: 17574859
-
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes.Mol Pharmacol. 2006 Feb;69(2):471-8. doi: 10.1124/mol.105.015040. Epub 2005 Nov 9. Mol Pharmacol. 2006. PMID: 16282221
-
Endocannabinoids, adipose tissue and lipid metabolism.J Neuroendocrinol. 2008 May;20 Suppl 1:124-9. doi: 10.1111/j.1365-2826.2008.01690.x. J Neuroendocrinol. 2008. PMID: 18426511 Review.
-
The endocannabinoid system: a new target for the regulation of energy balance and metabolism.Crit Pathw Cardiol. 2007 Jun;6(2):46-50. doi: 10.1097/HPC.0b013e318057d4b4. Crit Pathw Cardiol. 2007. PMID: 17667864 Review.
Cited by
-
Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.Rev Endocr Metab Disord. 2011 Sep;12(3):153-62. doi: 10.1007/s11154-011-9167-3. Rev Endocr Metab Disord. 2011. PMID: 21336842 Review.
-
Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity.Obesity (Silver Spring). 2011 Mar;19(3):505-13. doi: 10.1038/oby.2010.213. Epub 2010 Sep 30. Obesity (Silver Spring). 2011. PMID: 20885384 Free PMC article.
-
The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists.PLoS One. 2013 Oct 30;8(10):e77739. doi: 10.1371/journal.pone.0077739. eCollection 2013. PLoS One. 2013. PMID: 24204944 Free PMC article.
-
Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.Nutr Metab (Lond). 2011 Dec 27;8:93. doi: 10.1186/1743-7075-8-93. Nutr Metab (Lond). 2011. PMID: 22201701 Free PMC article.
-
The endocannabinoid system links gut microbiota to adipogenesis.Mol Syst Biol. 2010 Jul;6:392. doi: 10.1038/msb.2010.46. Mol Syst Biol. 2010. PMID: 20664638 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
