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. 2008 Jul;52(7):2680-2.
doi: 10.1128/AAC.00158-08. Epub 2008 Apr 21.

Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States

Andrea Endimiani  1 , Lenore L Carias, Andrea M Hujer, Christopher R Bethel, Kristine M Hujer, Federico Perez, Rebecca A Hutton, William R Fox, Geraldine S Hall, Michael R Jacobs, David L Paterson, Louis B Rice, Stephen G Jenkins, Fred C Tenover, Robert A Bonomo
Affiliations

Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States

Andrea Endimiani et al. Antimicrob Agents Chemother. 2008 Jul.

Abstract

The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids.

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References

    1. Ambrožič Avguštin, J., R. Keber, K. Žerjavič, T. Oražem, and M. Grabnar. 2007. Emergence of the quinolone resistance-mediating gene aac(6′)-Ib-cr in extended-spectrum-β-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005. Antimicrob. Agents Chemother. 51:4171-4173. - PMC - PubMed
    1. Bratu, S., D. Landman, R. Haag, R. Recco, A. Eramo, M. Alam, and J. Quale. 2005. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City. Arch. Intern. Med. 165:1430-1435. - PubMed
    1. Chiang, T., N. Mariano, C. Urban, R. Colon-Urban, L. Grenner, R. H. Eng, D. Huang, H. Dholakia, and J. J. Rahal. 2007. Identification of carbapenem-resistant Klebsiella pneumoniae harboring KPC enzymes in New Jersey. Microb. Drug Resist. 13:235-240. - PubMed
    1. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing: 17th informational supplement. CLSI document M100-S17. Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Edelstein, M., M. Pimkin, I. Palagin, I. Edelstein, and L. Stratchounski. 2003. Prevalence and molecular epidemiology of CTX-M extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. Antimicrob. Agents Chemother. 47:3724-3732. - PMC - PubMed

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