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. 1991 Nov 29;565(2):349-52.
doi: 10.1016/0006-8993(91)91669-r.

Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear

S Campeau  1 , M D Hayward, B T Hope, J B Rosen, E J Nestler, M Davis
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Free article

Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear

S Campeau et al. Brain Res. .
Free article

Abstract

Induction of the nuclear proto-oncogene c-fos in rat amygdala was investigated 30-40 min following the presentation of mild footshocks (unconditioned fear) or of contextual cues associated with similar footshocks 24 h earlier (conditioned fear). Initially, it was found that handling rats for the first time elevated c-fos mRNA levels, but this response could be blocked completely by repeated handling. Unconditioned and conditioned fear both elevated amygdala c-fos mRNA dramatically above control levels.

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