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. 2008 Apr 22:9:32.
doi: 10.1186/1471-2350-9-32.

Heritability of cardiovascular risk factors in a Brazilian population: Baependi Heart Study

Camila M de Oliveira  1 , Alexandre C Pereira, Mariza de Andrade, Júlia M Soler, José E Krieger
Affiliations

Heritability of cardiovascular risk factors in a Brazilian population: Baependi Heart Study

Camila M de Oliveira et al. BMC Med Genet. .

Abstract

Background: The heritability of cardiovascular risk factors is expected to differ between populations because of the different distribution of environmental risk factors, as well as the genetic make-up of different human populations.

Methods: The purpose of this analysis was to evaluate genetic and environmental influences on cardiovascular risk factor traits, using a variance component approach, by estimating the heritability of these traits in a sample of 1,666 individuals in 81 families ascertained randomly from a highly admixed population of a city in a rural area in Brazil.

Results: Before adjustment for sex, age, age2, and age x sex interaction, polygenic heritability of systolic (SBP) and diastolic (DBP) blood pressure were 15.0% and 16.4%, waist circumference 26.1%, triglycerides 25.7%, fasting glucose 32.8%, HDL-c 31.2%, total cholesterol 28.6%, LDL-c 26.3%, BMI 39.1%. Adjustment for covariates increased polygenic heritability estimates for all traits mainly systolic and diastolic blood pressure (25.9 and 26.2%, respectively), waist circumference (40.1%), and BMI (51.0%).

Conclusion: Heritability estimates for cardiovascular traits in the Brazilian population are high and not significantly different from other studied worldwide populations. Mapping efforts to identify genetic loci associated with variability of these traits are warranted.

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References

    1. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A. 2000;97:14478–14483. doi: 10.1073/pnas.97.26.14478. - DOI - PMC - PubMed
    1. Shmulewitz D, Heath SC, Blundell ML, Han Z, Sharma R, Salit J, Auerbach SB, Signorini S, Breslow JL, Stoffel M, Friedman JM. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci U S A. 2006;103:3502–3509. doi: 10.1073/pnas.0510156103. - DOI - PMC - PubMed
    1. McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL. A QTL genome scan of the metabolic syndrome and its component traits. BMC Genet. 2003;4 Suppl 1:S96. doi: 10.1186/1471-2156-4-S1-S96. - DOI - PMC - PubMed
    1. Goldin LR, Camp NJ, Keen KJ, Martin LJ, Moslehi R, Ghosh S, North KE, Wyszynski DF, Blacker D. Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13. Genet Epidemiol. 2003;25 Suppl 1:S78–89. doi: 10.1002/gepi.10288. - DOI - PubMed
    1. Oberg S, Ge D, Cnattingius S, Svensson A, Treiber FA, Snieder H, Iliadou A. Ethnic differences in the association of birth weight and blood pressure: the Georgia cardiovascular twin study. Am J Hypertens. 2007;20:1235–1241. doi: 10.1016/j.amjhyper.2007.07.012. - DOI - PMC - PubMed

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