Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 May:Appendix 1:A.1O.1-A.1O.23.
doi: 10.1002/0471142735.ima01os40.

Nomenclature of the human T cell receptor genes

Marie-Paule Lefranc  1
Affiliations

Nomenclature of the human T cell receptor genes

Marie-Paule Lefranc. Curr Protoc Immunol. 2001 May.

Abstract

The human T cell receptors (TcR) alpha-beta and gamma-delta are the products of four sets of genes on two chromosomes: T cell receptors alpha (TRA) and delta (TRD) on chromosome 14 at 14q11.2, T cell receptor beta (TRB) on chromosome 7 at 7q35, and T cell receptor gamma (TRG) on chromosome 7 at 7p15-p14. This appendix presents tabulated lists of the human TcR alpha, beta, gamma, and delta genes named in accordance with the International ImMunoGeneTics database and approved by the Human Genome Organization Nomenclature Committee in 1999. Two additional tables list corresponding nomenclatures for these genes.

PubMed Disclaimer

References

Literature Cited
    1. Arden, B., Clark, S.P., Kabelitz, D., and Mak, T.W. 1995. Human T-cell receptor variable gene segment families. Immunogenetics 42:455-500.
    1. Baer, R., Lefranc, M.-P., Minowada, J., Forster, A., Stinson, M.A., and Rabbitts, T.H. 1986. Organization of the T-cell receptor α-chain gene and rearrangement in human T-cell leukemias. Mol. Biol. Med. 3:265-277.
    1. Begley, C.G., Aplan, P.D., Davey, M.P., de Villartay, J.P., Cohen, D.I., Waldmann, T.A., and Kirsch, I.R. 1989. Demonstration of delta rec-pseudo J alpha rearrangement with deletion of the delta locus in a human stem-cell leukemia. J. Exp. Med. 170:339-342.
    1. Bories, J.C., Loiseau, P., d'Auriol, L., Gontier, C., Bensussan, A., Degos, L., and Sigaux, F. 1990. Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron. J. Exp. Med. 171:75-83.
    1. Buresi, C., Ghanem, N., Huck, S., Lefranc, G., and Lefranc, M.-P. 1989. Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and black African populations. Immunogenetics 29:161-172. [Published erratum appears in Immunogenetics 30:148.]
Key References
    1. Giudicelli, V. and Lefranc, M.-P. 1999. Ontology for immunogenetics: IMGT-ONTOLOGY. Bioinformatics 15:1047-1054.
    1. Lefranc and Rabbitts, 1990a. See above.
    1. Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G.E., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D., and Lefranc, M.-P. 2000. IMGT, the international ImMunoGeneTics database. Nucl. Acids Res. 28:219-221.
Internet Resources
    1. http://www.gdb.org
    1. http://www.gene.ucl.ac.uk/nomenclature
    1. http://imgt.cines.fr:8104
    1. http://imgt.cines.fr:8104/textes/IMGTrepertoire.html
    1. http://imgt.cines.fr:8104/textes/IMGTScientificChart.html

LinkOut - more resources