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. 2001 May:Appendix 1:A.1P.1-A.1P.37.
doi: 10.1002/0471142735.ima01ps40.

Nomenclature of the human immunoglobulin genes

Marie-Paule Lefranc  1
Affiliations

Nomenclature of the human immunoglobulin genes

Marie-Paule Lefranc. Curr Protoc Immunol. 2001 May.

Abstract

The human immunoglobulins (Ig) are the products of three unlinked sets of genes: the immunoglobulin heavy (IGH), the immunoglobulin kappa (IGK), and the immunoglobulin lambda (IGL) genes, localized on chromosome 14 (14q32.33), 2 (2p12), and 22 (22q11.2), respectively. This appendix presents tabulated lists of the human immunoglobulin heavy, kappa, and lambda genes named in accordance with the International ImMunoGeneTics database (IMGT) and approved by the Human Genome Organization (HUGO) Nomenclature Committee in 1999. Three additional tables list corresponding nomenclatures for these genes.

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References

Literature Cited
    1. Barbié, V. and Lefranc, M.-P. 1998. The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments. Exp. Clin. Immunogenet. 15:171-183.
    1. Bensmana, M., Huck, S., Lefranc, G., and Lefranc, M.-P. 1988. The human immunoglobulin pseudo-gamma IGHGP gene shows no major structural defect. Nucl. Acids Res. 16:3108.
    1. Bensmana, M., Chuchana, P., Lefranc, G., and Lefranc, M.-P. 1991. Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m(2) allele: Comparison with the nonallelic and allelic IGHA genes. Cytogenet. Cell Genet. 56:128.
    1. Blomberg, B.B., Rudin, C.M., and Storb, U. 1991. Identification and localization of an enhancer for the human lambda L chain Ig gene complex. J. Immunol. 147:2354-2358.
    1. Bottaro, A., Gallina, R., Brusco, A., Cariota, U., Boccazzi, C., Barilaro, M.R., Plebani, A., Ugazio, A.G., van Leeuwen, A.M., DeLange, G.G., et al. 1993. Familial clustering of IGHC deletions and duplications: Functional and molecular analysis. Immunogenetics 37:356-363.
Key References
    1. Giudicelli, V. and Lefranc, M.-P. 1999. Ontology for immunogenetics: IMGT-ONTOLOGY. Bioinformatics 15:1047-1054.
    1. Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G.E., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D., and Lefranc, M.-P. 2000. IMGT, the international ImMunoGeneTics database. Nucl. Acids Res. 28:219-221.
Internet Resources
    1. http://www.gene.ucl.ac.uk/nomenclature
    1. http://imgt.cines.fr:8104
    1. http://imgt.cines.fr:8104/textes/IMGTrepertoire.html
    1. http://imgt.cines.fr:8104/textes/IMGTrepertoire/1/locus/human/IGH/Hu_IGH...
    1. http://imgt.cines.fr:8104/textes/IMGTScientificChart.html

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