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Review
. 2007 May:Chapter 14:14.12.1-14.12.13.
doi: 10.1002/0471142735.im1412s77.

Toll-like receptors

Kiyoshi Takeda  1 , Shizuo Akira  2
Affiliations
Review

Toll-like receptors

Kiyoshi Takeda et al. Curr Protoc Immunol. 2007 May.

Abstract

This has led to the identification of several important roles for Toll receptors in mammals. This unit discusses mammalian Toll receptors (TLR1-10) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR-mediated signaling pathways and antibodies that are available to detect specific TLRs.

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References

Literature Cited

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    1. Alexopoulou, L., Thomas, V., Schnare, M., Lobet, Y., Anguita, J., Schoen, R.T., Medzhitov, R., Fikrig, E., and Flavell, R.A. 2002. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8:878-884.
    1. Asea, A., Rehli, M., Kabingu, E., Boch, J.A., Bare, O., Auron, P.E., Stevenson, M.A., and Calderwood, S.K. 2002. Novel signal transduction pathway utilized by extracellular HSP70: Role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277:15028-15034.

MeSH terms

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