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. 2008 Jun;47(6):642-651.
doi: 10.1097/CHI.0b013e31816bffb7.

A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

Katherine Gotham  1 , Susan Risi  2 , Geraldine Dawson  2 , Helen Tager-Flusberg  2 , Robert Joseph  2 , Alice Carter  2 , Susan Hepburn  2 , William McMAHON  2 , Patricia Rodier  2 , Susan L Hyman  2 , Marian Sigman  2 , Sally Rogers  2 , Rebecca Landa  2 , M Anne Spence  2 , Kathryn Osann  2 , Pamela Flodman  2 , Fred Volkmar  2 , Eric Hollander  2 , Joseph Buxbaum  2 , Andrew Pickles  2 , Catherine Lord  2
Affiliations

A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

Katherine Gotham et al. J Am Acad Child Adolesc Psychiatry. 2008 Jun.

Abstract

Objective: To replicate the factor structure and predictive validity of revised Autism Diagnostic Observation Schedule algorithms in an independent dataset (N = 1,282).

Method: Algorithm revisions were replicated using data from children ages 18 months to 16 years collected at 11 North American sites participating in the Collaborative Programs for Excellence in Autism and the Studies to Advance Autism Research and Treatment.

Results: Sensitivities and specificities approximated or exceeded those of the old algorithms except for young children with phrase speech and a clinical diagnosis of pervasive developmental disorders not otherwise specified.

Conclusions: Revised algorithms increase comparability between modules and improve the predictive validity of the Autism Diagnostic Observation Schedule for autism cases compared to the original algorithms.

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References

    1. Gotham K, Risi S, Pickles A, Lord C. The Autism Diagnostic Observation Schedule (ADOS): revised algorithms for improved diagnostic validity. J Autism Dev Disord. 2007;37:400–408. - PubMed
    1. Lord C, Risi S, Lambrecht L, et al. The Autism Diagnostic Observation Schedule–Generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30:205–223. - PubMed
    1. Joseph RM, Tager-Flusberg H, Lord C. Cognitive profiles and social-communicative functioning in children with autism spectrum disorders. J Child Psychol Psychiatry. 2002;43:807–821. - PMC - PubMed
    1. de Bildt A, Sytema S, Ketelaars C, et al. Interrelationship between Autism Diagnostic Observation Schedule–Generic (ADOS-G), Autism Diagnostic Interview-Revised (ADI-R), and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. J Autism Dev Disord. 2004;34:129–137. - PubMed
    1. Lord C, Rutter M, DiLavore P, Risi S. Autism Diagnostic Observation Schedule Manual. Los Angeles: Western Psychological Services; 1999.

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