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Comment
. 2008 Apr 15;111(8):3916-7.
doi: 10.1182/blood-2008-01-135376.

AML1 and Evi1: coconspirators in MDS/AML?

Timothy Graubert  1
Affiliations
Free article
Comment

AML1 and Evi1: coconspirators in MDS/AML?

Timothy Graubert. Blood. .
Free article

Abstract

In this issue of Blood, Watanabe-Okochi and colleagues use a mouse bone marrow transplantation model to demonstrate that mutant alleles of AML1 (RUNX1) can initiate a myelodysplastic syndrome (MDS) that progresses to acute myelogenous leukemia (AML) in association with overexpression of Evi1.

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  • AML1 mutations induced MDS and MDS/AML in a mouse BMT model.
    Watanabe-Okochi N, Kitaura J, Ono R, Harada H, Harada Y, Komeno Y, Nakajima H, Nosaka T, Inaba T, Kitamura T. Watanabe-Okochi N, et al. Blood. 2008 Apr 15;111(8):4297-308. doi: 10.1182/blood-2007-01-068346. Epub 2008 Jan 11. Blood. 2008. PMID: 18192504