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Comparative Study
. 2008 Jun;40(6):713-5.
doi: 10.1038/ng.148. Epub 2008 Apr 27.

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Andre Franke  1 , Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak, Stefan Schreiber
Affiliations
Comparative Study

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Andre Franke et al. Nat Genet. 2008 Jun.

Abstract

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.

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