Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008;7(4):11.
doi: 10.1186/jbiol73. Epub 2008 Apr 22.

How chemotherapy damages the central nervous system

Affiliations
Review

How chemotherapy damages the central nervous system

Christina A Meyers. J Biol. 2008.

Abstract

Chemotherapy adversely affects cognitive function both acutely and chronically, but little is known about the underlying mechanisms. A new study shows that short-term chemotherapy causes not only acute injury to progenitor cells, but also delayed damage to myelin.

PubMed Disclaimer

References

    1. Alvarez JA, Scully RE, Miller TL, Armstrong FD, Constine LS, Friedman DL, Lipschultz SE. Long-term effects of treatments for childhood cancers. Curr Opin Pediatr. 2007;19:23–31. doi: 10.1097/MOP.0b013e328013c89e. - DOI - PubMed
    1. Schagen SB, Muller MJ, Boogerd W, Mellenbergh GJ, van Dam FSAM. Change in cognitive function after chemotherapy: a prospective longitudinal study in breast cancer patients. J Natl Cancer Inst. 2006;98:1742–1745. - PubMed
    1. Wefel JS, Lenzi R, Theriault R, Davis RN, Meyers CA. The cognitive sequelae of standard dose adjuvant chemotherapy in women with breast cancer: results of a prospective, randomized, longitudinal trial. Cancer. 2004;100:2292–2299. doi: 10.1002/cncr.20272. - DOI - PubMed
    1. Ahles TA, Saykin AJ, Furstenberg CT, Cole B, Mott LA, Skalla K, Whedon MB, Bivens S, Mitchell T, Greenberg ER, Silberfarb PM. Neuropsychological impact of standard dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol. 2002;20:485–493. doi: 10.1200/JCO.20.2.485. - DOI - PubMed
    1. Winocur G, Vardy J, Binns MA, Kerr L, Tannock I. The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil on cognitive function in mice. Pharmacol Biochem Behav. 2006;85:66–75. doi: 10.1016/j.pbb.2006.07.010. - DOI - PubMed

MeSH terms

Substances