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Case Reports
. 2008 May;14(5):834-6.
doi: 10.3201/eid1405.071675.

New Saffold cardioviruses in 3 children, Canada

Yacine Abed  1 , Guy Boivin
Affiliations
Case Reports

New Saffold cardioviruses in 3 children, Canada

Yacine Abed et al. Emerg Infect Dis. 2008 May.

Abstract

In Canada, cardiovirus isolates related to Saffold virus were detected in nasopharyngeal aspirates from 3 children with respiratory symptoms. Polyprotein sequence of the Can112051-06 isolate had 91.2% aa identity with Saffold virus; however, EF and CD loops of the viral surface varied substantially.

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Figures

Figure 1
Figure 1
A) Cytopathic effects (round cells) observed 6 days after infection of rhesus monkey kidney (LLC-MK2) cells (second passage) with the Can112051-06 Saffold virus–like cardiovirus strain. B) Uninfected LLC-MK2 cells. Maginification ×10.
Figure 2
Figure 2
Comparison of amino acid sequences of the A) EF loop structure (part of the VP2 protein) and B) the CD loop structure (part of the VP1 protein) between Can112051-06 and other cardioviruses including Saffold virus (SAF-V), Theiler’s murine encephalomyelitis virus (TMEV), Theiler-like virus, encephalomyocarditis virus (EMCV), and Mengovirus. Amino acid differences between Can112051-06 and SAF-V are shaded.
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