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Review
. 2008 Jun;60(3):313-24.
doi: 10.1016/j.lungcan.2008.03.007. Epub 2008 Apr 25.

Gene expression profiling of non-small cell lung cancer

Sunil Singhal  1 , Daniel Miller, Suresh Ramalingam, Shi-Yong Sun
Affiliations
Review

Gene expression profiling of non-small cell lung cancer

Sunil Singhal et al. Lung Cancer. 2008 Jun.

Abstract

Functional genomics has emerged over the past 10 years as a novel technology to study genetic alterations. Gene expression arrays are one genomic technique employed to discover changes in the DNA expression that occur in neoplastic transformation. Microarrays have been applied to investigating lung cancer. Specific applications include discovering novel genetic changes that occur in lung tumors. Microarrays can also be applied to improve diagnosis, staging and discover prognostic markers. The eventual goal of this technology is to discover new markers for therapy and to customize therapy based on an individual tumor genetic composition. In this review, we present the current state of gene expression array technology in its application to lung cancer.

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Conflict of interest statement

Conflict of interest statement

The authors wish to disclose they have no conflict of interests.

Figures

Figure
Figure
Description of the genetic alterations in apoptotic signaling by using gene expression profiling [15].
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