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. 2008 Jul;80(1):93-7.
doi: 10.1016/j.eplepsyres.2008.03.007. Epub 2008 Apr 28.

Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis

Elena Alvarez-Barón  1 , Christian G Bien, Johannes Schramm, Christian E Elger, Albert J Becker, Susanne Schoch
Affiliations

Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis

Elena Alvarez-Barón et al. Epilepsy Res. 2008 Jul.

Abstract

Rasmussen encephalitis (RE) is a rare form of severe unihemispheric epilepsy established to be an autoimmune disease. Here we demonstrate the presence of autoantibodies against Munc18-1 in 20% of patients collective with biopsy-proven RE. Intriguingly, brain biopsy specimens of these patients showed a striking perivascular accentuated infiltration of B-lymphocytes and plasma cells, suggesting a subgroup of RE patients harboring Munc18-1 antibodies and concomitant B- and plasma cell infiltration.

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