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. 1976 Jan;8(1):1-6.
doi: 10.3109/00313027609094418.

Neoplasia in the rat induced by N-hydroxyphenacetin, a metabolite of phenacetin

I C Calder, D E Goss, P J Williams, C C Funder, C R Green, K N Ham, J D Tange

Neoplasia in the rat induced by N-hydroxyphenacetin, a metabolite of phenacetin

I C Calder et al. Pathology. 1976 Jan.

Abstract

N-hydroxyphenacetin, a phenacetin metabolite, was fed to rats as a 0.05-0.5% dietary supplement. After 9 months, tumours of the liver were found in 36 of 64 animals. One animal also developed a renal tumour. No tumours were found in control animals. The findings implicate phenacetin as a carcinogen and suggest that N-hydroxyphenacetin may be the metabolite responsible.

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