The effects of a soluble polymer and bone wax on sternal healing in an animal model
- PMID: 18442583
- DOI: 10.1016/j.athoracsur.2007.11.042
The effects of a soluble polymer and bone wax on sternal healing in an animal model
Erratum in
- Ann Thorac Surg. 2008 Oct;86(4):1403. Kang, Qian [added]
Abstract
Purpose: This study compares the effects of a soluble polymer hemostatic material and bone wax on sternal bone healing.
Description: Median sternotomies were performed on 20 New Zealand White rabbits, and sufficient polymer (Ostene; Ceremed Inc, Los Angeles CA) or bone wax (Bone Wax; Ethicon Inc, Somerville, NJ) was applied to achieve bone hemostasis. After 6 weeks, sternal healing was assessed using roentgenograms, histology, and mechanical strength testing.
Evaluation: Roentgenograms revealed normal bone healing in the polymer-treated group and nonunion in the bone wax group. Histology showed normal bone healing in the polymer group, with fibrotic scar tissue and the absence of new bone formation in the bone wax group. Mechanical strength testing showed that polymer-treated sternal segments were twice as strong as those treated with bone wax. They had a significantly higher flexural strength (2.53 +/- 0.43 vs. 1.29 +/- 0.37 megapascal [MPa]; p < 0.001) and Young's modulus (0.315 +/- 0.056 vs 0.146 +/- 0.031 MPa; p < 0.001).
Conclusions: The application of the polymer hemostatic material to the sternum resulted in significantly stronger union compared with the use of bone wax.
Comment in
-
The effects of a soluble polymer and bone wax on sternal healing in an animal model. Invited commentary.Ann Thorac Surg. 2008 May;85(5):1780. doi: 10.1016/j.athoracsur.2007.12.024. Ann Thorac Surg. 2008. PMID: 18442584 No abstract available.
Similar articles
-
The effects of a soluble polymer and bone wax on sternal healing in an animal model. Invited commentary.Ann Thorac Surg. 2008 May;85(5):1780. doi: 10.1016/j.athoracsur.2007.12.024. Ann Thorac Surg. 2008. PMID: 18442584 No abstract available.
-
Bone healing after median sternotomy: a comparison of two hemostatic devices.J Cardiothorac Surg. 2010 Nov 24;5:117. doi: 10.1186/1749-8090-5-117. J Cardiothorac Surg. 2010. PMID: 21106051 Free PMC article.
-
The influence of hemostatic agents on bone healing after sternotomy in a porcine model.Ann Thorac Surg. 2015 Mar;99(3):1005-11. doi: 10.1016/j.athoracsur.2014.10.016. Epub 2015 Jan 16. Ann Thorac Surg. 2015. PMID: 25601654
-
Bone Wax in Neurosurgery: A Review.World Neurosurg. 2018 Aug;116:72-76. doi: 10.1016/j.wneu.2018.04.222. Epub 2018 May 9. World Neurosurg. 2018. PMID: 29753076 Review.
-
Bone wax: a foreign body/giant cell reaction in the foot.Foot Ankle Spec. 2013 Jun;6(3):236-8. doi: 10.1177/1938640013484797. Epub 2013 Apr 2. Foot Ankle Spec. 2013. PMID: 23548587 Review.
Cited by
-
Development of novel waxy bone haemostatic agents composed of biodegradable polymers with osteogenic-enhancing peptides in rabbit models.Interdiscip Cardiovasc Thorac Surg. 2023 Nov 2;37(5):ivad170. doi: 10.1093/icvts/ivad170. Interdiscip Cardiovasc Thorac Surg. 2023. PMID: 37930044 Free PMC article.
-
Wax on, wax off: a case report discussing a potential pitfall of dissolvable bone wax substitutes such as Ostene® in neurosurgery.Acta Neurochir (Wien). 2025 Mar 8;167(1):65. doi: 10.1007/s00701-025-06473-z. Acta Neurochir (Wien). 2025. PMID: 40056269 Free PMC article.
-
The effects of surgicel and bone wax hemostatic agents on bone healing: An experimental study.Indian J Orthop. 2014 May;48(3):319-25. doi: 10.4103/0019-5413.129451. Indian J Orthop. 2014. PMID: 24932041 Free PMC article.
-
Use of a plant-based polysaccharide hemostat for the treatment of sternal bleeding after median sternotomy.J Cardiothorac Surg. 2015 Apr 24;10:59. doi: 10.1186/s13019-015-0263-4. J Cardiothorac Surg. 2015. PMID: 25902769 Free PMC article.
-
Evaluating the Efficacy of Water-Soluble Bone Wax (Tableau Wax) in Reducing Blood Loss in Spinal Fusion Surgery: A Randomized, Controlled, Pilot Study.Medicina (Kaunas). 2023 Aug 25;59(9):1545. doi: 10.3390/medicina59091545. Medicina (Kaunas). 2023. PMID: 37763664 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources