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. 2008 May;105(5):e77-81.
doi: 10.1016/j.tripleo.2008.01.024.

Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues

Mônica Maria Denadae de Campos-Pinto  1 , Danilo Alessandro de Oliveira, Marco Aurélio Versiani, Yara Teresinha Correa Silva-Sousa, Manoel Damião de Sousa-Neto, Danyel Elias da Cruz Perez
Affiliations

Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues

Mônica Maria Denadae de Campos-Pinto et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May.

Abstract

Objective: The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.

Study design: Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.

Results: In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.

Conclusion: Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.

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