Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues
- PMID: 18442740
- DOI: 10.1016/j.tripleo.2008.01.024
Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues
Abstract
Objective: The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.
Study design: Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.
Results: In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.
Conclusion: Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.
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