Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008 Jul;52(7):2480-5.
doi: 10.1128/AAC.01118-07. Epub 2008 Apr 28.

Connection between trimethoprim-sulfamethoxazole use and resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

Pauliina Kärpänoja  1 , Solja T Nyberg, Miika Bergman, Tinna Voipio, Pirkko Paakkari, Pentti Huovinen, Hannu Sarkkinen; Finnish Study Group for Antimicrobial Resistance (FiRe Network)
Collaborators, Affiliations
Comparative Study

Connection between trimethoprim-sulfamethoxazole use and resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

Pauliina Kärpänoja et al. Antimicrob Agents Chemother. 2008 Jul.

Abstract

The association between trimethoprim-sulfamethoxazole use and resistance among the major respiratory tract pathogens was investigated by comparing regional consumption of the drug to regional resistance in the following year in 21 central hospital districts in Finland. A total of 23,530 Streptococcus pneumoniae isolates, 28,320 Haemophilus influenzae isolates, and 14,138 Moraxella catarrhalis isolates were tested for trimethoprim-sulfamethoxazole susceptibility during the study period (1998-2004). Among the S. pneumoniae isolates, a statistically significant connection was found between regional consumption and resistance. No statistically significant connection was found between regional trimethoprim-sulfamethoxazole use and resistance among H. influenzae and M. catarrhalis isolates. According to our results, it seems that only in pneumococci can the development of trimethoprim-sulfamethoxazole resistance be influenced by restricting its use. However, trimethoprim-sulfamethoxazole remains an important antimicrobial agent because of its reasonable price. Hence, resistance to trimethoprim-sulfamethoxazole among these pathogens needs continuous monitoring.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
SXT and TMP consumption in Finland from 1987 to 2003 (DDD/1,000 inhabitants/day), including sales figures for pharmacies and hospitals. J01EE, all SXT combinations; J01EA, TMP. Figures for SXT for the period 1987-1989 were not available.
FIG. 2.
FIG. 2.
SXT resistance (%) in S. pneumoniae (Spn), H. influenzae (Hi), and M. catarrhalis (Mc) in Finland from 1988 to 2004.
See this image and copyright information in PMC

References

    1. Arason, V. A., A. Gunnlaugsson, J. A. Sigurdson, H. Erlendsdottir, S. Gudmundsson, and K. G. Kristinsson. 2002. Clonal spread of resistant pneumococci despite diminished antimicrobial use. Microb. Drug Resist. 8:187-192. - PubMed
    1. Baquero, F., G. Baquero-Artiago, R. Canton, and C. Garcia-Rey. 2002. Antibiotic consumption and resistance selection in Streptococcus pneumoniae. J. Antimicrob. Chemother. 50(Suppl. S2):27-37. - PubMed
    1. Bean, D. C., D. M. Livermore, I. Papa, and L. M. C. Hall. 2005. Resistance among Escherichia coli to sulphonamides and other antimicrobials now little used in man. J. Antimicrob. Chemother. 56:962-964. - PubMed
    1. Bergman, M., S. Huikko, M. Pihlajamäki, P. Laippala, E. Palva, P. Huovinen, H. Seppälä, and the Finnish Study Group for Antimicrobial Resistance (FiRe Network). 2004. Effect of macrolide consumption on erythromycin resistance in Streptococcus pyogenes in Finland in 1997-2001. Clin. Infect. Dis. 38:1251-1256. - PubMed
    1. Calatayud, L., C. Ardanuy, E. Cercenado, A. Fenoll, E. Bouza, R. Pallares, R. Martin, and J. Linares. 2007. Serotypes, clones and mechanisms of resistance of erythromycin-resistant Streptococcus pneumoniae isolates collected in Spain. Antimicrob. Agents Chemother. 51:3240-3246. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources