Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 May;37(5):1052-60.
doi: 10.1039/b708459p. Epub 2008 Mar 20.

SERS--a single-molecule and nanoscale tool for bioanalytics

Janina Kneipp  1 , Harald Kneipp, Katrin Kneipp
Affiliations
Review

SERS--a single-molecule and nanoscale tool for bioanalytics

Janina Kneipp et al. Chem Soc Rev. 2008 May.

Abstract

Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).

PubMed Disclaimer

LinkOut - more resources