Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;4(3):267-85.
doi: 10.1007/s11302-008-9096-0. Epub 2008 Apr 29.

Purinergic receptors in the splanchnic circulation

Manuela Morato  1 , Teresa Sousa, António Albino-Teixeira
Affiliations

Purinergic receptors in the splanchnic circulation

Manuela Morato et al. Purinergic Signal. 2008 Sep.

Abstract

There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to other vasoactive substances. Adenosine exerts its effects by interacting with adenosine receptors. These are metabotropic G-protein coupled receptors and include four subtypes, A(1), A(2A), A(2B) and A(3). Adenosine triphosphate (ATP) is a co-transmitter in vascular neuroeffector junctions and is known to activate two distinct types of P2 receptors, P2X (ionotropic) and P2Y (metabotropic). ATP can exert either vasoconstrictive or vasorelaxant effects, depending on the P2 receptor subtype involved. Splanchnic vascular beds are of particular interest, as they receive a large fraction of the cardiac output. This review focus on purinergic receptors role in the splanchnic vasomotor control. Here, we give an overview on the distribution and diversity of effects of purinergic receptors in splanchnic vessels. Pre- and post-junctional receptormediated responses are summarized. Attention is also given to the interactions between purinergic receptors and other receptors in the splanchnic circulation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0165-6147(02)00038-X', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0165-6147(02)00038-x'}, {'type': 'PMC', 'value': 'PMC8653507', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC8653507/'}, {'type': 'PubMed', 'value': '12559763', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12559763/'}]}
    2. Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G (2003) Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci 24:52–55 - PMC - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1124/pr.58.3.3', 'is_inner': False, 'url': 'https://doi.org/10.1124/pr.58.3.3'}, {'type': 'PMC', 'value': 'PMC3471216', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC3471216/'}, {'type': 'PubMed', 'value': '16968944', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16968944/'}]}
    2. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006) International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281–341 - PMC - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '1818941', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/1818941/'}]}
    2. Albino-Teixeira A, Matias A, Polonia J, Azevedo I (1991) Blockade of adenosine receptors causes hypertension and cardiovascular structural changes in the rat. J Hypertens Suppl 9:S196–197 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1007/BF00167217', 'is_inner': False, 'url': 'https://doi.org/10.1007/bf00167217'}, {'type': 'PubMed', 'value': '1658665', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/1658665/'}]}
    2. Allgaier C, Greber R, Hertting G (1991) Studies on the interaction between presynaptic alpha 2-adrenoceptors and adenosine A1 receptors located on noradrenergic nerve terminals. Naunyn-Schmiedeberg’s Arch Pharmacol 344:187–192 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/hep.510270402', 'is_inner': False, 'url': 'https://doi.org/10.1002/hep.510270402'}, {'type': 'PubMed', 'value': '9580129', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/9580129/'}]}
    2. Atucha NM, Ortiz MC, Fortepiani LA, Ruiz FM, Martinez C, Garcia-Estan J (1998) Role of cyclic guanosine monophosphate and K+ channels as mediators of the mesenteric vascular hyporesponsiveness in portal hypertensive rats. Hepatology (Baltimore, Md 27:900–905 - PubMed

LinkOut - more resources