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. 1976 Sep;73(9):3040-4.
doi: 10.1073/pnas.73.9.3040.

Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor

F Golini, S S Thach, C H Birge, B Safer, W C Merrick, R E Thach

Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor

F Golini et al. Proc Natl Acad Sci U S A. 1976 Sep.

Abstract

Encephalomyocarditis viral RNA has previously been shown to outcompete host cellular mRNA has for translation in vitro in crude and fractionated protein synthesizing systems. In the present communication it is shown that the competition is regulated by an initiation factor or complex of factors, and not the 40S initiation complex per se. The factor primarily involved is the murine equivalent of a component present in a partially purified preparation of rabbit initiation factor M3. Both the murine and rabbit factors are clearly messenger discriminatory.

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References

    1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3392-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 May;73(5):1559-63 - PubMed
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    1. Proc Natl Acad Sci U S A. 1976 Feb;73(2):375-80 - PubMed
    1. Nat New Biol. 1973 Apr 4;242(118):136-40 - PubMed

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