Review
doi: 10.1080/10543409108835010.
One-sided or two-sided p values: which most appropriately address the question of drug efficacy?
Affiliations
- PMID: 1844684
- DOI: 10.1080/10543409108835010
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Review
One-sided or two-sided p values: which most appropriately address the question of drug efficacy?
J Biopharm Stat.
1991.
Abstract
Whether a one-sided or a two-sided p value should be used for reporting the results of an analysis should be determined by the a priori question the investigation seeks to answer. It is concluded that one-sided p values are appropriate in clinical trials whose objective is to provide definitive, confirmatory evidence of efficacy of pharmaceutical compounds.
Comment in
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Directional decision for a two-tailed alternative.J Biopharm Stat. 1996 May;6(2):211-8. doi: 10.1080/10543409608835134. J Biopharm Stat. 1996. PMID: 8732915 No abstract available.
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