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Comment
. 2008 Aug;29(5):732-3; author reply 733.
doi: 10.1097/MAO.0b013e318173fcea.

Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30

Stefan K Plontke, Anthony A Mikulec, Alec N Salt
Comment

Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30

Stefan K Plontke et al. Otol Neurotol. 2008 Aug.
No abstract available

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Figures

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Solid symbols: Measured MP concentrations reported by Bird et al. (1) plotted as a function of the time between drug application and sampling. Lines: Predicted time courses derived from simulation of the application and sampling protocol. The solid curve shows the best fit to the data, derived by minimizing the sum of squares of differences between measured and calculated values (inset graph). Dashed lines show curves calculated for 0.5x (13.3 min) and 2x (54 min) clearance values and scaled to the same peak amplitude, to demonstrate the expected time course as clearance rates were varied.
See this image and copyright information in PMC

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References

    1. Bird PA, Begg EJ, Zhang M, et al. Intratympanic Versus Intravenous Delivery of Methylprednisolone to Cochlear Perilymph. Otol Neurotol. 2007;28:1124–1130. - PubMed
    1. Plontke SK, Salt AN. Quantitative interpretation of corticosteroid pharmacokinetics in inner ear fluids using computer simulations. Hear.Res. 2003;182:34–42. - PubMed
    1. Bachmann G, Su J, Zumegen C, et al. Permeabilität der runden Fenstermembran für Prednisolon-21-Hydrogensuccinat. HNO. 2001;49:538–542. - PubMed
    1. Hahn H, Kammerer B, DiMAuro A, et al. Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hear.Res. 2006;212:236–244. - PMC - PubMed
    1. Plontke SK, Biegner T, Kammerer B, et al. Dexamethasone Concentration Gradients Along Scala Tympani After Application to the Round Window Membrane Otol Neurotol 2008;Epub ahead of print Feb 11. - PMC - PubMed

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