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Review
. 2008 May-Jun;53(3):188-194.
doi: 10.1016/j.jmwh.2007.12.015.

The quadrivalent human papillomavirus vaccine: potential factors in effectiveness

Nancy J Zonfrillo, Barbara Hackley
Review

The quadrivalent human papillomavirus vaccine: potential factors in effectiveness

Nancy J Zonfrillo et al. J Midwifery Womens Health. 2008 May-Jun.

Abstract

Cervical cancer, caused by human papillomavirus (HPV) infection, is the second most common female cancer in the world, causing over a quarter of a million deaths worldwide every year. The quadrivalent HPV vaccine (Gardasil) has the potential to significantly reduce morbidity and mortality associated with cervical disease. However, a variety of factors affect the vaccine's success, including exposure to HPV prior to vaccination, duration of protection provided by the vaccine, the in vivo interaction between HPV serotypes, and variation in HPV serotype prevalence worldwide. This article describes the pathophysiology of HPV infection, efficacy and safety of the quadrivalent HPV vaccine, factors that may influence the vaccine's effectiveness in reducing cervical cancer rates, and recommendations for maximizing this effectiveness.

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Summary for patients in

  • HPV, cervical cancer, and you.
    [No authors listed] [No authors listed] J Midwifery Womens Health. 2008 May-Jun;53(3):263-264. doi: 10.1016/j.jmwh.2008.02.011. J Midwifery Womens Health. 2008. PMID: 18672495 No abstract available.

References

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    1. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27.
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    1. National Cancer Institute. Cervical Cancer Screening (PDQ®). 2007. Available from: www.cancer.govcancertopicspdqscreeningcervicalHealthProfessionalpage3. [Accessed August 6, 2007].

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