CaMKII: new tricks for an old dog
- PMID: 18455979
- PMCID: PMC2655315
- DOI: 10.1016/j.cell.2008.04.018
CaMKII: new tricks for an old dog
Abstract
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal signaling molecule in both the brain and the heart. In this issue of Cell, Erickson et al. (2008) demonstrate a mechanism for CaMKII activation by reactive oxygen species that provides a direct link between kinase activation and cardiac dysfunction.
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A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.Cell. 2008 May 2;133(3):462-74. doi: 10.1016/j.cell.2008.02.048. Cell. 2008. PMID: 18455987 Free PMC article.
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