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Comment
. 2008 May 2;133(3):401-2.
doi: 10.1016/j.cell.2008.04.017.

A different TIPE of immune homeostasis

Eric C Freundt  1 , Nicolas Bidere, Michael J Lenardo
Affiliations
Comment

A different TIPE of immune homeostasis

Eric C Freundt et al. Cell. .

Abstract

Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.

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