Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 May 2;133(3):403-14.
doi: 10.1016/j.cell.2008.04.013.

Tenets of PTEN tumor suppression

Leonardo Salmena  1 , Arkaitz Carracedo, Pier Paolo Pandolfi
Affiliations
Free article

Tenets of PTEN tumor suppression

Leonardo Salmena et al. Cell. .
Free article

Abstract

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources