Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Apr;20(2):158-61.
doi: 10.1016/j.coi.2008.03.015. Epub 2008 May 2.

BAFF and the plasticity of peripheral B cell tolerance

Jason E Stadanlick  1 , Michael P Cancro
Affiliations
Review

BAFF and the plasticity of peripheral B cell tolerance

Jason E Stadanlick et al. Curr Opin Immunol. 2008 Apr.

Abstract

BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

The authors declare no conflicts of interest.

References

    1. Allman DM, Ferguson SE, Cancro MP. Peripheral B cell maturation. I Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J Immunol. 1992;149:2533–2540. - PubMed
    1. Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 1993;151:4431–4444. - PubMed
    1. Nossal GJ, Pike BL. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc Natl Acad Sci U S A. 1980;77:1602–1606. - PMC - PubMed
    1. Nossal GJ, Pike BL. Evidence for the clonal abortion theory of B-lymphocyte tolerance. J Exp Med. 1975;141:904–917. - PMC - PubMed
    1. Hartley SB, Crosbie J, Brink R, Kantor AB, Basten A, Goodnow CC. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 1991;353:765–769. - PubMed

Publication types

Substances