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. 2008:104:287-90.
doi: 10.1007/978-3-211-75718-5_59.

Role of statins in cerebral vasospasm

T Sugawara  1 , R Ayer, J H Zhang
Affiliations

Role of statins in cerebral vasospasm

T Sugawara et al. Acta Neurochir Suppl. 2008.

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.

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Figures

Fig. 1
Fig. 1
Proposed pathways of protection against cerebral vasospasm by statins. eNOS Endothelial nitric oxide synthase; NADPH oxidase nicotinamide adenine dinucleotide phosphate oxidase; NO nitric oxide; PI3K phosphatidyl-inositol-3 kinase; RhoK Rho kinase; ROS reactive oxygen species; ↑ upregulation; ↓ inhibition or down-regulation; *proposed targets of statins
See this image and copyright information in PMC

References

    1. Bochaton-Piallat ML, Gabbiani F, Redard M, Desmouliere A, Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. Am J Pathol. 1995;146:1059–1064. - PMC - PubMed
    1. Borel CO, McKee A, Parra A, Haglund MM, Solan A, Prabhakar V, Sheng H, Warner DS, Niklason L. Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke. 2003;34:427–433. - PubMed
    1. Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med. 2000;6:1362–1367. - PubMed
    1. Budzyn K, Marley PD, Sobey CG. Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension. J Pharmacol Exp Ther. 2005;313:1248–1253. - PubMed
    1. Budzyn K, Marley PD, Sobey CG. Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol Sci. 2006;27:97–104. - PubMed

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