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. 2008 May 12;205(5):1003-7.
doi: 10.1084/jem.20080569. Epub 2008 May 5.

Crippling HIV one mutation at a time

Todd M Allen  1 , Marcus Altfeld
Affiliations

Crippling HIV one mutation at a time

Todd M Allen et al. J Exp Med. .

Abstract

Accumulating data suggest that not all human immunodeficiency virus (HIV)-1-specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine.

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References

    1. Goulder, P.J., and D.I. Watkins. 2004. HIV and SIV CTL escape: implications for vaccine design. Nat. Rev. Immunol. 4:630–640. - PubMed
    1. Walker, B.D., and B.T. Korber. 2001. Immune control of HIV: the obstacles of HLA and viral diversity. Nat. Immunol. 2:473–475. - PubMed
    1. Goepfert, P.A., W. Lumm, P. Farmer, P. Matthews, A. Prendergast, J. Carlson, C.A. Derdeyn, J. Tang, R.A. Kaslow, A. Bansal, et al. 2008. Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients. J. Exp. Med. 205:1009–1017. - PMC - PubMed
    1. Quinones-Mateu, M.E., D.M. Moore-Dudley, O. Jegede, J. Weber, and E.J. Arts. 2008. Viral drug resistance and fitness. Adv. Pharmacol. 56:257–296. - PubMed
    1. Gandhi, R.T., A. Wurcel, E.S. Rosenberg, M.N. Johnston, N. Hellmann, M. Bates, M.S. Hirsch, and B.D. Walker. 2003. Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus. Clin. Infect. Dis. 37:1693–1698. - PubMed