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. 2008 Aug;52(8):2919-22.
doi: 10.1128/AAC.00323-08. Epub 2008 May 5.

In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates

Sheng-Yuan Ruan  1 , Chen-Chen Chu, Po-Ren Hsueh
Affiliations

In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates

Sheng-Yuan Ruan et al. Antimicrob Agents Chemother. 2008 Aug.

Abstract

Voriconazole, posaconazole, caspofungin, micafungin, and anidulafungin demonstrated potent in vitro activities against 286 invasive Candida isolates. Analysis of the fluconazole susceptibilities of 204 bloodstream Candida glabrata isolates revealed a rapid shift from susceptible (64% in 1999 to 2001 to 19% in 2007) to susceptible-dose dependent (27% in 1999 to 2001 and 75% in 2007).

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Figures

FIG. 1.
FIG. 1.
Intravenous and oral fluconazole consumption (black bars) and trends of susceptibility to fluconazole (broken lines) among 204 Candida glabrata isolates recovered from the blood of patients with candidemia over a 9-year period.
See this image and copyright information in PMC

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