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. 2008 Jul;466(7):1598-604.
doi: 10.1007/s11999-008-0272-x. Epub 2008 May 6.

VEGF expression in patellar tendinopathy: a preliminary study

Alexander Scott  1 , Øystein Lian, Roald Bahr, David A Hart, Vincent Duronio
Affiliations

VEGF expression in patellar tendinopathy: a preliminary study

Alexander Scott et al. Clin Orthop Relat Res. 2008 Jul.

Abstract

Vascular function and angiogenesis are regulated by vascular endothelial growth factor-A (VEGF). The purpose of this preliminary study was to address the following questions: Is VEGF expression in the patellar tendon more prevalent in patients with patellar tendinopathy than in individuals with normal, pain-free patellar tendons? Which cell populations express VEGF in normal and tendinopathic tendon? Is there a difference in symptom duration between VEGF+ and VEGF- tendons? We collected patellar tendon tissue from 22 patients undergoing open débridement of the patellar tendon and from 10 patients undergoing intramedullary nailing of the tibia. VEGF expression was assessed immunohistochemically. Relevant inflammatory and repair cell types were immunolabeled. VEGF expression was absent from control tendons, but was present in a subset of patients with histopathological evidence of angiofibroblastic tendinosis. VEGF was expressed in the intimal layer of tendon vessels, but was absent in other cell types. Patients demonstrating VEGF expression in the patellar tendon had a shorter symptom duration (12 +/- 7.8 months) than patients with no detectable VEGF (32.8 +/- 23.5 months). VEGF may contribute to the vascular hyperplasia that is a cardinal feature of symptomatic tendinosis, particularly in cases with more recent onset.

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Figures

Fig. 1A–D
Fig. 1A–D
(A) VEGF is expressed in endothelial cells in an area of expanded endotendon (New Fuschin, original magnification × 200). (B) Higher-power views demonstrate endothelial cells with cytoplasmic VEGF staining (New Fuschin, original magnification × 600). Note the absence of staining in the tunica media. (C) Higher-power views demonstrate endothelial cells with cytoplasmic VEGF staining (New Fuschin, original magnification × 600). (D) A capillary is shown. Higher-power views demonstrate endothelial cells with cytoplasmic VEGF staining (New Fuschin, original magnification × 400). Staining is localized to the tunica intima of an arteriole.
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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1097/00007890-200206150-00003', 'is_inner': False, 'url': 'https://doi.org/10.1097/00007890-200206150-00003'}, {'type': 'PubMed', 'value': '12084990', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12084990/'}]}
    2. Abraham D, Taghavi S, Riml P, et al. VEGF-A and -C but not -B mediate increased vascular permeability in preserved lung grafts. Transplantation. 2002;73:1703–1706. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0736-0266(03)00107-4', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0736-0266(03)00107-4'}, {'type': 'PubMed', 'value': '14554207', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/14554207/'}]}
    2. Alfredson H, Lorentzon M, Backman S, Backman A, Lerner UH. cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. J Orthop Res. 2003;21:970–975. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1007/s00167-003-0391-6', 'is_inner': False, 'url': 'https://doi.org/10.1007/s00167-003-0391-6'}, {'type': 'PubMed', 'value': '14520512', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/14520512/'}]}
    2. Alfredson H, Ohberg L, Forsgren S. Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc. 2003;11:334–338. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '9617396', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/9617396/'}]}
    2. Alfredson H, Pietila T, Jonsson P, Lorentzon R. Heavy-load eccentric calf muscle training for the treatment of chronic Achilles tendinosis. Am J Sports Med. 1998;26:360–366. - PubMed
    1. Andersson GB. Epidemiology of occupational neck, shoulder disorders. In: Gordon SL, Blair SJ, Fine LJ, eds. Repetitive Motion Disorders of the Upper Extremity. Bethesda, MD: American Academy of Orthopaedic Surgeons; 1994:31–42.

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