Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Mar;8(2):162-6.
doi: 10.1007/s11910-008-0026-x.

Pathophysiology of restless legs syndrome: evidence for iron involvement

James R Connor  1
Affiliations
Review

Pathophysiology of restless legs syndrome: evidence for iron involvement

James R Connor. Curr Neurol Neurosci Rep. 2008 Mar.

Abstract

Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.

PubMed Disclaimer

References

    1. J Neuropathol Exp Neurol. 2007 May;66(5):383-8 - PubMed
    1. Dev Neurosci. 1985;7(3):133-60 - PubMed
    1. Sleep Med. 2004 May;5(3):231-5 - PubMed
    1. Mov Disord. 1999 Jan;14(1):141-5 - PubMed
    1. J Neurol Sci. 2004 May 15;220(1-2):59-66 - PubMed

Publication types

MeSH terms

LinkOut - more resources