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. 2008 Jul 1;36(Web Server issue):W347-51.
doi: 10.1093/nar/gkn239. Epub 2008 May 6.

ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data

Alexey V Antonov  1 , Thorsten Schmidt, Yu Wang, Hans W Mewes
Affiliations

ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data

Alexey V Antonov et al. Nucleic Acids Res. .

Abstract

ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of 'complex functions'. A 'Complex function' is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.

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Figures

Figure 1.
Figure 1.
ProfCom output table ‘Top enriched categories of degree 1’ for the considered example.
Figure 2.
Figure 2.
ProfCom output table ‘Top enriched categories of degree 3’ for the considered example.
See this image and copyright information in PMC

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