Comparative Study
doi: 10.1038/349305a0.
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
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- PMID: 1846229
- DOI: 10.1038/349305a0
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Comparative Study
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
Nature.
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Abstract
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.
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