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. 1991 Feb;11(2):1171-5.
doi: 10.1128/mcb.11.2.1171-1175.1991.

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs

T Lorca  1 , D Fesquet, F Zindy, F Le Bouffant, M Cerruti, C Brechot, G Devauchelle, M Dorée
Affiliations

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs

T Lorca et al. Mol Cell Biol. 1991 Feb.

Abstract

Inhibition of okadaic acid-sensitive phosphatases released the cyclin degradation pathway from its inhibited state in extracts prepared from unfertilized Xenopus eggs arrested at the second meiotic metaphase. It also switched on cyclin protease activity in a permanent fashion in interphase extracts prepared from activated eggs. Even after cdc2 kinase inactivation, microinjection of okadaic acid-treated interphase extracts pushed G2-arrested recipient oocytes into the M phase, suggesting that the phosphatase inhibitor stabilizes the activity of an unidentified factor which shares in common with cdc2 kinase the maturation-promoting factor activity.

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