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. 1991 Feb 15;251(4995):802-4.
doi: 10.1126/science.1846706.

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product

D P Bottaro  1 , J S Rubin, D L Faletto, A M Chan, T E Kmiecik, G F Vande Woude, S A Aaronson
Affiliations

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product

D P Bottaro et al. Science. .

Abstract

Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.

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