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. 2008 May 10;336(7652):1049-51.
doi: 10.1136/bmj.39493.646875.AE.

Going from evidence to recommendations

Gordon H Guyatt  1 , Andrew D Oxman, Regina Kunz, Yngve Falck-Ytter, Gunn E Vist, Alessandro Liberati, Holger J Schünemann; GRADE Working Group
Collaborators, Affiliations

Going from evidence to recommendations

Gordon H Guyatt et al. BMJ. .

Erratum in

  • BMJ. 2008 Jun 21;336(7658): doi:10.1136/bmj.a402

Abstract

The GRADE system classifies recommendations made in guidelines as either strong or weak. This article explores the meaning of these descriptions and their implications for patients, clinicians, and policy makers

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Conflict of interest statement

Competing interests: All authors are involved in the dissemination of GRADE, and GRADE’s success has a positive influence on their academic careers. Authors listed on the byline have received travel reimbursement and honoraria for presentations that included a review of GRADE’s approach to rating quality of evidence and grading recommendations. GHG acts as a consultant to UpToDate; his work includes helping UpToDate in their use of GRADE. HJS is documents editor and methodologist for the American Thoracic Society; one of his roles in these positions is helping implement the use of GRADE. HJS is supported by “The human factor, mobility and Marie Curie Actions Scientist Reintegration European Commission Grant: IGR 42192—GRADE.” AL is helping the use of GRADE by different institutions in the Italian health service, and in this role he has implemented GRADE to produce clinical recommendations in oncology through Grant No 249 (2005-7), Bando Ricerca Finalizzata, Ministero della Salute, Roma, Italy.

Figures

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Fig 1 Varying thresholds of major gastrointestinal bleeding found acceptable by patients and physicians for prevention of eight strokes in 100 patients
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Fig 2 Representations of quality of evidence and strength of recommendations
See this image and copyright information in PMC

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