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Comment
. 2008 May 15;111(10):4838-9.
doi: 10.1182/blood-2008-02-139048.

"Regulating" rheumatoid arthritis via autotransplantation

Steven Z Pavletic  1 , Daniel H Fowler
Affiliations
Comment

"Regulating" rheumatoid arthritis via autotransplantation

Steven Z Pavletic et al. Blood. .

Abstract

Using a mouse model of inducible autoimmune arthritis that mimics some aspects of the human disease, Roord and colleagues identify a role for regulatory T cells (Tregs) both for modulation of disease and as a therapeutic component of autologous bone marrow transplantation (aBMT).

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests. ■

Figures

None
Conditioning followed by aBMT leads to a rapid decrease in the severity of arthritis; the clinical effect is reduced by depletion of CD25+ cells. See the complete figure in the article beginning on page 5233.
See this image and copyright information in PMC

Comment on

References

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