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. 1991 Feb;173(3):1021-6.
doi: 10.1128/jb.173.3.1021-1026.1991.

The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase

M Ikeda  1 , M Wachi, H K Jung, F Ishino, M Matsuhashi
Affiliations

The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase

M Ikeda et al. J Bacteriol. 1991 Feb.

Abstract

Amplification of the mraY gene, previously called open reading frame Y (ORF-Y, 1,080 bp), at 2 min in the chromosome map of Escherichia coli enhanced the activity of UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase (EC 2.7.8.13). This enzyme catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-N-acetylmuramoyl-pentapeptide and undecaprenyl-phosphate, the first step in the lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans. The enhanced enzyme activity was sensitive to tunicamycin, and the amino tunicamycin-sensitive N-acetylglucosamine-1-phosphate transferase of Saccharomyces cerevisiae. Very probably mraY is the structural gene for the above enzyme.

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References

    1. Methods Enzymol. 1987;153:3-11 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 Apr;57(4):1010-2 - PubMed
    1. Nucleic Acids Res. 1990 Feb 25;18(4):1058 - PubMed
    1. Nucleic Acids Res. 1990 Jul 11;18(13):4014 - PubMed
    1. Res Microbiol. 1990 Jan;141(1):89-103 - PubMed

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