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. 2008 May-Jun;10(5-6):571-5.
doi: 10.1080/10286020801966906.

Cytotoxic sesquiterpenoids from Vernonia bockiana

Jun Huo  1 , Sheng-Ping Yang, Bo-Jun Xie, Shang-Gao Liao, Li-Ping Lin, Jian Ding, Jian-Min Yue
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Cytotoxic sesquiterpenoids from Vernonia bockiana

Jun Huo et al. J Asian Nat Prod Res. 2008 May-Jun.

Abstract

Two new sesquiterpenoids, vernobockolides A (1) and B (2), along with five known ones, piptocarphin C (3), piptocarphin F (4), piptocarphin A (5), hirsutolide (6), and beta-d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR. Among them, compounds 2-6 showed strong cytotoxic activities against mouse lymphoid tumor cell line P388 with the IC(50) values of 1.81, 1.32, 0.77, and 0.73 microM, respectively.

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