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. 2008 Jun 15;51(8):1424-30.
doi: 10.1016/j.toxicon.2008.03.027. Epub 2008 Mar 29.

OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae

Yousra Abdel-Mottaleb  1 , Thomas Vandendriessche, Elke Clynen, Bart Landuyt, Amir Jalali, Hossein Vatanpour, Liliane Schoofs, Jan Tytgat
Affiliations

OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae

Yousra Abdel-Mottaleb et al. Toxicon. .

Abstract

The first Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae (OdK2) was purified, sequenced and characterized physiologically. OdK2 consists of 38 amino acids, including six conserved cysteine and a C-terminal lysine residue, as revealed by the unique use of a quadrupole ion cyclotron resonance Fourier-transform mass spectrometer. Based on multiple sequence alignments, OdK2 was classified as alpha-KTX3.11. The pharmacological effects of OdK2 were studied on a panel of eight different cloned K(+) channels (vertebrate Kv1.1-Kv1.6, Shaker IR and hERG) expressed in Xenopus laevis oocytes. Interestingly, OdK2 selectively inhibits the currents through Kv1.3 channels with an IC50 value of 7.2+/-2.7nM.

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