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Comparative Study
. 1991 Feb 15;88(4):1172-6.
doi: 10.1073/pnas.88.4.1172.

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI

P Vieira  1 , R de Waal-Malefyt, M N Dang, K E Johnson, R Kastelein, D F Fiorentino, J E deVries, M G Roncarolo, T R Mosmann, K W Moore
Affiliations
Comparative Study

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI

P Vieira et al. Proc Natl Acad Sci U S A. .

Abstract

We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.

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References

    1. Int Immunol. 1990;2(9):821-32 - PubMed
    1. J Immunol. 1986 Jul 1;137(1):i-x - PubMed
    1. Eur J Immunol. 1985 May;15(5):520-5 - PubMed
    1. Cell Immunol. 1989 Sep;122(2):440-9 - PubMed
    1. J Exp Med. 1989 Dec 1;170(6):2081-95 - PubMed

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