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. 1994;2(3):115-9.
doi: 10.1155/S1064744994000499.

Comparison of culture and rapid enzyme immunoassay for the detection of group B streptococcus in high-risk pregnancies

M J Dinsmoor  1 , H P Dalton, T C Peng, J T Christmas, S Sayahtaheri-Altaie, K Harvey, J P Vandorsten
Affiliations

Comparison of culture and rapid enzyme immunoassay for the detection of group B streptococcus in high-risk pregnancies

M J Dinsmoor et al. Infect Dis Obstet Gynecol. 1994.

Abstract

Objective: The purpose of this study was to evaluate the Equate Strep B(R) test for clinical use in patients at high risk for complications from group B streptococcus (GBS) disease.

Methods: Vaginoperineal swabs were obtained from patients with preterm premature rupture of the membranes and/or preterm labor and semiquantitative GBS cultures and Equate(R) assay were performed.

Results: From May 14, 1990, to April 30, 1992, 650 patients were enrolled; 626 had both culture and Equate(R) results available, of whom 24% were colonized with GBS. The sensitivity, specificity, positive predictive value, and negative predictive value of the rapid assay were 28%, 84%, 35%, and 79%, respectively. Although the prevalence of GBS was higher in patients with ruptured membranes compared with those with intact membranes, rupture of membranes did not affect test sensitivity or specificity.

Conclusions: We conclude that the Equate(R) rapid assay is not a sensitive method of GBS detection in high-risk patients.

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