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. 2008 Jul;142(1):115-8.
doi: 10.1111/j.1365-2141.2008.07195.x. Epub 2008 May 8.

Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative

Jasmin Otten  1 , Alexander Schultze, Philippe Schafhausen, Svenja Otterstetter, Judith Dierlamm, Carsten Bokemeyer, Tim H Brummendorf, Walter Fiedler, Sonja Loges
Affiliations

Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative

Jasmin Otten et al. Br J Haematol. 2008 Jul.

Abstract

The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P < 0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.

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