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. 2008 Jun 1;18(11):3178-82.
doi: 10.1016/j.bmcl.2008.04.074. Epub 2008 May 1.

Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

Mark T Bilodeau  1 , Adrienne E Balitza, Jacob M Hoffman, Peter J Manley, Stanley F Barnett, Deborah Defeo-Jones, Kathleen Haskell, Raymond E Jones, Karen Leander, Ronald G Robinson, Anthony M Smith, Hans E Huber, George D Hartman
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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

Mark T Bilodeau et al. Bioorg Med Chem Lett. .

Abstract

A series of naphthyridine and naphthyridinone allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been optimized to have potent dual activity against the activated kinase as well as the activation of Akt in cells. One molecule in particular, compound 17, has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model.

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