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. 2008 Jun 7;6(11):1895-7.
doi: 10.1039/b804701d. Epub 2008 Apr 14.

Epigenetic remodeling of the fungal secondary metabolome

Russell B Williams  1 , Jon C Henrikson, Ashley R Hoover, Andrlynn E Lee, Robert H Cichewicz
Affiliations

Epigenetic remodeling of the fungal secondary metabolome

Russell B Williams et al. Org Biomol Chem. .

Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

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