Comparative Study
doi: 10.1038/bjc.1976.179.
BCG treatment of malignant pleural effusions in the rat
- PMID: 184810
- PMCID: PMC2025260
- DOI: 10.1038/bjc.1976.179
Item in Clipboard
Comparative Study
BCG treatment of malignant pleural effusions in the rat
Br J Cancer.
1976 Oct.
Free PMC article
Abstract
Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour injection. In contrast, active specific immunotherapy by repeated s.c. injection of viable or radiation-attenuated tumour cells in admixture with BCG was unsuccessful, and did not improve the response to intrapleural BCG treatment.
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